Discussion of the dissertation of doctoral student "Reem Mahdi Saleh"
The public discussion took place for the Doctoral student (Reem Mahdi Saleh) at Anbar University, College of Science, Department of Biology, on Tuesday 12/11/2024 in Ibn Sina Hall, for his tagged thesis
" Effect of Chitosan-stabilized silver nanoparticles on gene expression of quorum sensing and some virulence factors of Staphylococcus aureus "
The discussion committee consisted of:
Prof. Dr. Haifa Hadi Hassani - University of Baghdad - College of Science - Chairman
Prof. Dr. Muthanna Hamed Hassan - Anbar University - College of Science - Member
Assist. Prof. Dr. Israa Adnan Abdel Jalil - Anbar University - College of Pharmacy - Member
Assist. Prof. Dr. Ali Abdul Sharad - Anbar University - College of Science - Member
Assist. Prof. Dr. Khalil Thabet Hassan - Anbar University - College of Science - Member
Assist. Prof. Dr. Omar Mohammad Hassan - Anbar University - College of Science - Member and Supervisor
The aim of this study is to green synthesis of silver nanoparticles from Acacia glauca leaves which has not been used before, stabilized by chitosan, and test their effect phenotypically against multi-drug-resistant Staphylococcus aureus also upon gene expression level for a number of quorum sensing and virulence genes.
Results revealed high rates of inhibition of synthesized silver nanoparticles with minimum inhibition concentration (4.2 µg/ml), and the ability of different concentrations of Cs-AgNps for S. aureus biofilm inhibition. The pathogenic isolates treated with sub-lethal of Cs-AgNps had a substantial effect in the downregulation of AGR system genes (agrA, agrB, RNAIII) and virulence genes (mecA, hla, coa, spa, psm, rot) proving the antibacterial effective role of CS-AgNps amidst the worldwide spread of antibiotics resistance
.jpeg)
.jpeg)
.jpeg)
.jpeg)