" Inhibitory effect of biosynthesized silver nanoparticle on phenotypic and molecular of the efflux pump of Acinetobacter baumannii"

The discussion committee consisted of:

Prof. Dr. Shahab Ahmed Lafi - University of Anbar - College of Medicine - Chairman

Prof. Dr. Suzan Saadi Hussein - University of Anbar - College of Science - Member

Prof. Dr. Muthanna Hamid Hussein - University of Anbar College of Sciences - Member

Prof. Dr. Jamal Mal Allah Rizej - University of Baghdad - College of Sciences - Member

Assist. Prof. Dr. Laith Musleh Najib - University of Anbar - College of Sciences- Member

Assist. Prof. Dr. Muthanna Badie Farhan Anbar - University - Upper Euphrates Basin Center - Member and Supervisor 

  Hospital-acquired infections represent a significant threat to patient safety, leading to elevated mortality rates due to their resistance to conventional antibiotic treatments. One notable pathogen in this category is Acinetobacter baumannii, a multidrug- resistant (MDR-AB) bacterium. Therefore, we discussed alternative methods for eliminating antibiotic-resistant pathogens, particularly A. baumannii (MDR-AB) isolates. One of these methods is nanotechnology, considered a modern and essential approach with broad prospects for treating these pathogens. Our research is unique because we utilized a combination of silver nanoparticles and antimicrobial such as probiotics extracted from beneficial bacteria to discover them synergistic effect on Acinetobacter baumannii. The effect of the combination of silver nanoparticles and probiotics was highly significant and greater than the effect of silver nanoparticles alone. This was confirmed using the gene expression of virulence genes.