The public discussion took place for the master’s student (Mahmoud Abdul Qader Hamad) Department of Chemistry- College of Science - University of Anbar on Thursday, May 29, 2025, in Ibn Sina Hall. for his tagged thesis

" Study the influence of oxidative stress and some hormones in men with irritable bowel syndrome"

The discussion committee consisted of:

 The aim of this study is Significant elevation in oxidative stress markers was observed in IBS patients compared to healthy controls, indicated by increased MDA levels and decreased levels of SOD, CAT, and TAOC (p < 0.0001). No significant association was found between age or Body Mass Index (BMI) and the occurrence of IBS (p>0.05). Hormonal alterations included a marked decrease in serotonin levels, a significant increase in cholecystokinin (CCK), and reduced selenium levels in IBS patients versus controls (p < 0.05). Strong correlations among biomarkers were observed, most notably a significant inverse relationship between CAT and MDA (r = -0.764, p < 0.001). Receiver Operating Characteristic (ROC) analysis demonstrated high diagnostic accuracy of the studied biomarkers, reinforcing their potential clinical utility. The results highlight a potential role of oxidative stress and hormonal imbalances (particularly serotonin and CCK) in the pathophysiology of IBS, suggesting their possible application in diagnosis and therapeutic strategies.