Discussion of the dissertation of doctoral student

Discussion of the dissertation of doctoral student " Hetaf Shalal Farhan"

The public discussion took place for the Doctoral student (Hetaf Shalal Farhan) at Anbar University, College of Science, Department of Biology, on Sunday, June 1, 2025, in Ibn Sina Hall, for his tagged thesis

" Oxidative Stress, Expression of Some MicroRNAs and Polymorphism of GPX-1 Gene in Hemodialysis Patients"

The discussion committee consisted of:

University of Anbar - College of Sciences - President

Prof. Dr. Mohammed Qais Abdul

University of Samarra - College of Education - Member

Prof. Dr. Mustafa Ali Abdul Rahman

University of Anbar - College of Sciences - Member

Prof. Dr. Ahmed Abdul Jabbar Suleiman

University of Anbar - College of Sciences - member

Prof. Dr. Mustafa Nihad Juma

University of Anbar - College of Medicine - member

Assist. Prof. Dr. Hazem Ismail Ghazai

University of Anbar - College of Sciences, Member and Supervisor

Assist. Prof. Dr. Mariam Ibrahim Salman

University of Anbar - College of Education for Girls, Member and Supervisor

Assist. Prof. Dr. Nagham Khadir Mahdi

 This study had an aimed to explore the correlation between oxidative stress markers and various antioxidants with expression of some microRNAs associated with kidney failure, also impact of GPX-1 SNP rs1050450 gene in hemodialysis patients. The current study showed the levels of SOD and GPX were lower in patients than controls. The comparison of CAT and GR indicated insignificant differences between patients and controls. The study observed the levels of GSH, vitamin C, and vitamin A were low in patients than controls. Insignificant difference was obtained for vitamin E between patients and controls. The current study observed the levels of malondialdehyde and 8-Hydroxy-Deoxyguanosine were high in patients compared than controls. Additionally, the current study indicated the CC genotype "wild type" was generally associated with normal GPX-1 activity. The study showed lack of CT and TT suggests a low prevalence or absence of the allele in population. T allele was associated with reduced GPX-1 activity and higher oxidative stress levels.

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